

Goddamnit this one got me pretty good


Goddamnit this one got me pretty good
Not necessarily. A lot of podcasts are hosted by places that detect your ip and splice in location-targeted ads for each individual download. Hence OP’s struggle with timestamps.
Even off of Spotify etc, the source is poisoned.


DHH with a pants-on-head stupid argument just because he hates the big players in tech? Must be a day ending in Y again.


The Nobel committees frequently give prizes in an area that really have more to do with other areas. Six of the last ten Nobels in Chemistry have been explicitly biology focused. Two more were materials science stuff, so maybe half chemistry. Only two were what I’d consider actual chemistry.
But this one is pretty rough. The Nobel Prize in Physics goes to setting the world’s energy reserves on fire so coked-up executives’ lines can go up and basement-dwellers can generate waifus with big tiddies. UGH


One even worse thing about smart tv’s - they come with a bunch of free “channels” you can watch. If you have streaming services or cable, who cares?
Except the people that don’t – rural folk who never would pay for cable – gobble it up. And it’s all right wing propaganda garbage. From Fox News to Newsmax, they’ve got every kind of anxiety-inducing conspiracy-laden “news” you can watch.
The crazy thing is that the Dutch (or the people who lived in what is now the Low Countries) were winning that war pretty handily until like eight thousand years ago. Then they lost Doggerland to the sea.
Their descendants remember, though. The Dutch will rise again.


The industry standard is HPLC (high performance liquid chromatography). Those things go for tens of thousands of dollars up front, plus maintenance and consumables.
If there was a less costly way of doing it, you bet companies would have settled on that by now.


make the best decisions they can
I would recommend an HPLC and a competent analytical chemist to gather data and decide whether or not a batch is safe to consume.


This has been posted to a bunch of different communities, and I’m gonna be a stick in the mud each time.
I’m a process chemist. I do this for a living. I’ve made kilo-scale batches of pharmaceuticals at work that have gone through the regulatory process and made it into people. I went to school for ten years to do this.
This is a colossally dangerous thing.
Every time you run a chemical synthesis, you generate impurities. Slightly different temperatures, concentrations, reagent quality, and a million other things will vary the identities and concentrations of those impurities in your product.
The nature of biochemistry is that most compounds, even at very small concentrations, can have effects. Usually bad ones. So drugs have tight specs on how much of each potential impurity can be present. Usually it’s in the 0.1% range, but sometimes a lot lower.
Detection of impurities at that level cannot be done with ‘hacker’ gear in your garage. So if you do this, you’re going to be taking unknown quantities of unknown impurities.
There are trade-offs. If you’re definitely gonna die without the medicine, then the worst that can happen is you die faster, or more painfully. If it’s medicine to maintain quality of life, then you might die fast and painfully.
I’m not saying the current system is good at all. Medicine is too expensive. It shouldn’t be limited by right wing nutjobs. Those things are true. Those things require a solution.
This is not a good solution.


I sort of feel bad about raining on the parade of the person distilling isopropanol in his garage earlier, but it really is dangerous.
But most of us chemists also need to be reminded of it. To the point that someone had to write a paper whose entire point is “don’t distill isopropanol”.


Please, don’t do this thing.


The issue with isopropanol peroxide formation is that exposing it to air – even when just using it, like when you’re cleaning parts – starts the process. The air in the head space of your containers is also enough to form them over time. You don’t necessarily need to see solids in the containers for it to be dangerous, since they’ll crystallize out as you concentrate the solution during distillation.
It’s also a numbers game. It probably won’t explode the first time you do it. But there’s a chance each time. Do it enough, and you’ll have an incident.
There are chemical reductants that can clear peroxides. For industrial scale isopropanol distillation, I’m not sure what they use. It may be that they just never distill down to the point that peroxides concentrate to a dangerous level.


I love EnF. But I assure you, organic peroxide formers are scarier.


No no no no no.
I’m a chemist. Organic chemistry PhD, now a process chemist in the industry. I do this for a living. Do not distill isopropanol that’s been exposed to air for any meaningful length of time.
Isopropanol slowly reacts with oxygen in the air to generate peroxides that, when you concentrate them down, EXPLODE. Source. Sorry, not an open access journal. But please take my word for it.
Unless you have a way of confirming the peroxide levels in your isopropanol are near zero, do not concentrate it down by distillation. You’ll blow up your glassware, which will probably expose what you’re distilling to your heat source, which will generate a secondary fireball.
PLEASE do not do this.
I feel bad for laughing at this


I’m in the middle of a TNG rewatch. This is my next episode. Every time I look at the thumbnail, I just can’t. Even though Best of Both Worlds is so soon after.


Technical people that move into management usually (but not always) suffer from something I’ve started calling management brain rot. They’re exposed to the spreadsheet warriors and their corporate jargon, and it doesn’t take long for the good ones to give up and the bad ones to thrive in a, let’s call it, “low-information environment.”


And also that Lukashenko was widely known for preferring a more reasonable policy toward Ukraine, and he was set to inherit the presidency upon Putin’s death, and that Putin was like right about to die because he became the leader of Russia like 68 years ago
clearing the launch tower during a test launch with an experimental rocket that has no payload and no humans aboard is success
managing to get into the right orbit without aborting using a rocket that’s launched since the 60s and is lit with giant matchsticks is success
You, an idiot: “these are comparable”
They do, and that’s the point.